Formulation: A crystalline solid
Formal Name: 1-(2-fluorophenyl)-N-[1-(2-fluoro-4-pyridinyl)-1H-pyrazol-3-yl]-cyclopropanecarboxamide
Purity: ≥98%
Formula Markup: C18H14F2N4O
Formula Weight: 340,3
Shelf life (days): 730
CAS Number: 2227482-41-7
Notes: ELOVL1-27 is an inhibitor of ELOVL fatty acid elongase 1 (ELOVL1; IC50 = 900 nM).{61941} It reduces lysohexacosanoylphosphatidylcholine (LPC(C26:0)) synthesis in HEK293 cells (IC50 = 13 nM), as well as in primary fibroblasts isolated from patients with cerebral adrenoleukodystrophy (CALD) or adrenomyeloneuropathy (AMN; IC50s = 15-43 nM), neurodegenerative diseases characterized by rapid inflammatory demyelination of the CNS. ELOVL1-27 (2, 16, and 32 mg/kg) reduces blood LPC(C26:0) levels in wild-type mice and rats. It also reduces CNS levels of LPC(C26:0) in an ABCD1-/- mouse model of ALD when administered at a dose of 1 or 10 mg/kg per day for at least three months.
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