EMD 534085, CAS 858668-07-2

Formulation: A solid

Formal Name: N-[2-(dimethylamino)ethyl]-N′-[[(2R,4aS,5R,10bS)-3,4,4a,5,6,10b-hexahydro-5-phenyl-9-(trifluoromethyl)-2H-pyrano[3,2-c]quinolin-2-yl]methyl]-urea

Purity: ≥99%

Formula Markup: C25H31F3N4O2

Formula Weight: 476,5

Shelf life (days): 1460

CAS Number: 858668-07-2

Notes: EMD 534085 is an inhibitor of the kinesin spindle protein Eg5 (IC50 = 8 nM).{64340} It inhibits proliferation of HCT116 colon cancer cells (IC50 = 30 nM), as well as induces mitotic arrest and apoptosis in HL-60 leukemia cells.{64340,64341} EMD 534085 (15 and 30 mg/kg) reduces tumor growth in a COLO 205 colon cancer mouse xenograft model.{64340}

• SKU: CAY35719-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35719-5
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK
• Application: Reinstoffe