Formulation: A crystalline solid
Formal Name: 2-[[2-oxo-2-[(tetrahydro-2-oxo-3-thienyl)amino]ethyl]thio]-acetic acid
Purity: ≥98%
Formula Markup: C8H11NO4S2
Formula Weight: 249,3
Shelf life (days): 1460
CAS Number: 84611-23-4
Notes: Erdosteine is a mucolytic agent and an antioxidant.{47790,47791,47792} It inhibits LPS-induced IκB kinase (IKK) activity, NF-κB-mediated transcription, and production of IL-6 and IL-1β in RAW 264.7 cells.{47790} Erdosteine (7.5 mg/kg) prevents depletion of renal catalase and glutathione peroxidase (GPX) and increases in renal malondialdehyde (MDA) and nitric oxide (NO) levels in a rat model of nephrotoxicity induced by cisplatin (Item No. 13119).{47791} It reduces spinal cord lipid peroxidation and destruction of spinal motor neurons in a rabbit model of spinal cord ischemia and reperfusion injury induced by thoracoabdominal aortic clamping. Erdosteine (150 mg/kg) reduces lung weight, MDA and protein carbonyl levels, and macrophage and neutrophil accumulation in a mouse model of acute lung injury induced by oleic acid (Item Nos. 90260 / 24659).{47792} Formulations containing erdosteine have been used in the treatment of chronic obstructive pulmonary disease (COPD).
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