Erlotinib (hydrochloride), CAS 183319-69-9

Formulation: A solid

Formal Name: N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine, monohydrochloride

Purity: ≥98%

Formula Markup: C22H23N3O4 • HCl

Formula Weight: 429,9

Shelf life (days): 1460

CAS Number: 183319-69-9

Notes: Erlotinib is an EGFR inhibitor (Ki = 2.7 nM).{18353} It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM.{69208} Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM.{18351} Erlotinib (25 mg/kg) reduces EGF-induced EGFR autophosphorylation in an HN-5 head and neck cancer mouse xenograft model.{69208} Formulations containing erlotinib have been used in the treatment of various cancers.

• SKU: CAY35517-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35517-1
• Green Labware: No
• Package Unit: 1 g
• Quantity Unit: STK
• Application: Reinstoffe