Formulation: A solid
Formal Name: (1S)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile, monoethanedioate
Purity: ≥98%
Formula Markup: C20H21FN2O • C2H2O4
Formula Weight: 414,4
Shelf life (days): 1460
CAS Number: 219861-08-2
Notes: Escitalopram is a selective serotonin (5-HT) reuptake inhibitor (SSRI) and the (S) isomer of citalopram (Item No. 14572) and (R)-citalopram.{38120} It selectively binds to SERT (Ki = 0.89 nM) over the norepinephrine and dopamine transporters (Kis = >10,000 and 8,150 nM, respectively) and inhibits 5-HT reuptake in rat brain synaptosomes (IC50 = 2.1 nM).{64079,38121} Escitalopram reduces immobility in the forced swim test in mice (ED50 = 12 mg/kg), indicating anti-depressant-like activity, and increases exploratory behavior in the black-and-white box test in mice with a minimal effective dose (MED) of 0.49 mg/kg, indicating anxiolytic-like activity.{64080} Escitalopram (20 µM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide (Item No. 10681).{54655} Formulations containing escitalopram have been used in the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD).
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