Formulation: A solid
Formal Name: (1R,2R,5S,5aR,7aS,11S,11aS,11bR,12R)-1,5,5a,7,7a,11,11a,11b-octahydro-1,11-dihydroxy-5a,8,11a,12-tetramethyl-2,5-methanonaphth[1,2-d]oxepin-4,6,10(2H)-trione
Purity: ≥98%
Formula Markup: C19H24O6
Formula Weight: 348,4
Shelf life (days): 1460
CAS Number: 23062-24-0
Notes: Eurycomalactone is a quassinoid that has been found in E. longifolia and has diverse biological activities.{68639,68640,68641} It inhibits TNF-α-induced NF-κB activation in a reporter assay using HEK293 cells (IC50 = 0.5 µM).{68639} Eurycomalactone also inhibits viral infection of HCT-8 cells with human coronavirus OC43 (HCoV-OC43) and Vero cells with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in cellular immunoassays (IC50s = 0.37 and 0.51 µM, respectively).{68640} It is cytotoxic to A549 human lung and HeLa cervical cancer cells when used at concentrations of 10 and 100 µM.{68641}
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