Formulation: A solid
Formal Name: 2α,3α,19-trihydroxy-urs-12-en-28-oic acid
Purity: ≥98%
Formula Markup: C30H48O5
Formula Weight: 488,7
Shelf life (days): 1460
CAS Number: 53155-25-2
Notes: Euscaphic acid is a triterpene that has been found in R. alceaefolius and has diverse biological activities.{64668,64669,64670} It inhibits the proliferation of CNE-1 and C666-1 nasopharyngeal carcinoma cells when used at concentrations of 5 and 10 µg/ml.{64668} Euscaphic acid inhibits acetylcholinesterase (AChE; IC50 = 35.9 µM) and α-glucosidase (IC50 = 24.9 µM).{64669} It reduces the production of nitric oxide (NO) and levels of inducible nitric oxide synthase (iNOS) and COX-2 in LPS-stimulated RAW 264.7 cells.{64670} Euscaphic acid (10 mg/kg) reduces serum IgE and IgG2a levels, ear tissue mast cell infiltration, and pruritis in a mouse model of difluoroethane- and 2,4-dinitrochlorobenzene-induced atopic dermatitis.{64671}
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