FB23-2, CAS 2243736-45-8

Formulation: A solid

Formal Name: 2-[[2,6-dichloro-4-(3,5-dimethyl-4-isoxazolyl)phenyl]amino]-N-hydroxy-benzamide

Purity: ≥98%

Formula Markup: C18H15Cl2N3O3

Formula Weight: 392,2

Shelf life (days): 1460

CAS Number: 2243736-45-8

Notes: FB23-2 is an inhibitor of the mRNA N6-methyladenosine (m6A) demethylase fat mass and obesity-associated (FTO) protein (IC50 = 2.6 µM).{62801} It reduces the proliferation of NB4 and Mono-Mac-6 cells (IC50s = 0.8 and 1.5 µM, respectively). FB23-2 increases m6A levels in isolated human bone marrow cells, as well as suppresses the proliferation of isolated human bone marrow cells and a panel of acute myeloid leukemia (AML) cells (IC50s = 1.9-5.2 µM). In vivo, FB23-2 (2 mg/kg) delays disease onset and increases survival in a Mono-Mac-6 mouse xenograft model.

• SKU: CAY36606-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36606-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe