FDW028, CAS 2768426-49-7

Formulation: A solid

Formal Name: 2-[[(4-ethylphenyl)methyl]amino]-5-[[(phenylmethyl)amino]methyl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-ol

Purity: ≥98%

Formula Markup: C22H24N6O

Formula Weight: 388,5

Shelf life (days): 1460

CAS Number: 2768426-49-7

Notes: FDW028 is an inhibitor of fucosyltransferase 8 (FUC8).{69791} It binds to FUC8 (Kd = 5.486 µM) and inhibits core fucosylation in HCT-8 and SW480 colorectal cancer (CRC) cells. FDW028 (50 µM) induces degradation of B7-H3, also known as CD276, via chaperone-mediated autophagy (CMA) in the same cells. In vivo, FDW028 (10 and 20 mg/kg) reduces tumor volume and increases survival in an SW480 mouse xenograft model.

• SKU: CAY39543-25
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39543-25
• Package Unit: 25 mg
• Quantity Unit: STK