FerroLOXIN-1, CAS 2773428-48-9

Formulation: A solution in methyl acetate

Formal Name: 1-(3-fluorophenyl)-N-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-4-phenyl-1H-imidazol-2-amine

Purity: ≥90%

Formula Markup: C23H16F5N3

Formula Weight: 429,4

Shelf life (days): 1095

CAS Number: 2773428-48-9

Notes: FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.{71038} It selectively inhibits the peroxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (Item No. 25871) by the 15-LO-2/PEBP1 complex over 15-LO-2 alone in cell-free assays when used at a concentration of 0.25 µM. FerroLOXIN-1 inhibits RSL3-induced ferroptosis in primary human bronchial epithelial cells (IC50 = 84 nM). It increases survival in a mouse model of total body irradiation when administered at a dose of 25 mg/kg.

• SKU: CAY39325-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39325-5
• Package Unit: 5 mg
• Quantity Unit: STK