Formulation: A solid
Formal Name: (2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
Purity: ≥98%
Formula Markup: C17H16O5
Formula Weight: 300,3
Shelf life (days): 1095
CAS Number: 37308-75-1
Notes: Flavokawain C is a chalcone that has been found in kava and has enzyme inhibitory and anticancer activities.{65770,65771,65772} It inhibits collagenase and elastase in cell-free assays (IC50s = 62.05 and 17.6 µM, respectively).{65770} It is cytotoxic to HCT116, HT-29, MCF-7, A549, and Ca Ski cancer cells (IC50s = 12.75, 39, 47.63, 40.28, and 39.88 µM, respectively).{65771} Flavokawain C (20, 40, and 60 µM) induces apoptosis and cell cycle arrest at the G1 phase in HCT116 cells. In vivo, flavokawain C (1 and 3 mg/kg) reduces tumor volume and induces intratumoral necrosis and apoptosis in an HCT116 mouse xenograft model.{65772}
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