FLT3-IN-3, CAS 2229050-90-0

Formulation: A solid

Formal Name: N2-(trans-4-aminocyclohexyl)-9-cyclopentyl-N6-[4-(4-morpholinylmethyl)phenyl]-9H-purine-2,6-diamine

Purity: ≥98%

Formula Markup: C27H38N8O

Formula Weight: 490,6

Shelf life (days): 1460

CAS Number: 2229050-90-0

Notes: FLT3-IN-3 is an inhibitor of FMS-related tyrosine kinase 3 (FLT3).{61858} It inhibits wild-type, FLT3D835Y, and FLT3 bearing internal-tandem duplication (FLT3-ITD; IC50s = 13, 8, and 3 nM, respectively). FLT3-IN-3 suppresses the growth of MV4-11 acute myeloid leukemia (AML) cells that express FLT3-ITD (GI50 = 7 nM). It induces cell cycle arrest at the G1 phase and apoptosis in the same cells. FLT3-IN-3 (10 mg/kg) reduces intratumor FLT3-ITD autophosphorylation in a MV4-11 mouse xenograft model.

• SKU: CAY36106-100
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 36106-100
• Green Labware: No
• Package Unit: 100 mg
• Quantity Unit: STK
• Application: Reinstoffe