Formulation: A solid
Formal Name: 7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, dihydrochloride
Purity: ≥95%
Formula Markup: C11H14N4O4 • 2HCl
Formula Weight: 339,2
Shelf life (days): 1460
Notes: Forodesine is a purine nucleoside derivative and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively).{55073} It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = 9002864). Forodesine inhibits the proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells.{55074} In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).{55073}
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