Formulation: A solid
Formal Name: (2S)-1-[5-[(2,3-dihydro-1,4-dioxino[2,3-b]pyridin-7-yl)sulfonyl]-3,4,5,6-tetrahydropyrrolo[3,4-c]pyrrol-2(1H)-yl]-2-hydroxy-2-(2-methyl-4-benzoxazolyl)-ethanone
Purity: ≥98%
Formula Markup: C23H22N4O7S
Formula Weight: 498,5
Shelf life (days): 1460
CAS Number: 2413991-74-7
Notes: FT709 is an inhibitor of ubiquitin-specific protease 9X (USP9X; IC50 = 82 nM).{69711} It is selective for USP9X over a panel of 20 deubiquitinases (IC50s = >25 µM for all). FT709 (10 µM) decreases the levels of the USP9X substrate centrosomal protein of 55 kDa (CEP55), as well as zinc-finger protein 598 (ZNF598), makorin 1 (MKRN1), and MKRN2, which are involved in the ribosomal quality control pathway, and inhibits the ribosomal stalling response to polyA tracts, a translation quality-control process, in a reporter assay using HEK293 cells.
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