Formulation: A 25 µg/ml 1:1 solution in acetonitrile:water
Formal Name: (2R,2′R)-1,2,3-Propane-1,2,3-13C3-tricarboxylic-1,2,3-13C3 acid, 1,1′-[(1S,2R)-1-[(2S,4R,9R,11S,12S)-12-amino-4,9,11-trihydroxy-2-(methyl-13C)tridecyl-1,2,3,4,5,6,7,8,9,10,11,12,13-13C13]-2-[(1R)-1-(methyl-13C)pentyl-1,2,3,4,5-13C5]-1,2-ethanediyl-1,2-13C2] ester
Purity: ≥95%
Formula Markup: [13C]34H59NO15
Formula Weight: 755,6
Shelf life (days): 730
CAS Number: 1217458-62-2
Notes: Fumonisin B1-13C34 (FB1-13C34) is intended for use as an internal standard for the quantification of FB1 (Item No. 62580) by GC- or LC-MS. FB1 is a mycotoxin that has been found in F. moniliforme.{1632} It inhibits ceramide synthase (IC50 = 0.1 µM for the rat liver enzyme).{5545} FB1 induces DNA fragmentation and apoptosis in CV-1 cells when used at concentrations of 5 and 25 µM, respectively.{10371} It is cytotoxic to primary rat hepatocytes and induces hepatocyte nodule formation, a marker of cancer initiation, in rats when administered at a dose of 500 mg/kg for 21 days.{61109} It has been detected in corn and corn-based foods and livestock feeds.{61110}
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