Formulation: A solid
Formal Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-piperazine, dihydrochloride
Purity: ≥98%
Formula Markup: C28H32N2O • 2HCl
Formula Weight: 485,5
Shelf life (days): 1460
CAS Number: 67469-75-4
Notes: GBR 12783 is a dopamine uptake inhibitor (IC50 = 13 nM in rat striatal synaptosomes).{51540} It is selective for inhibition of dopamine uptake over norepinephrine or serotonin (5-HT) uptake (IC50s = 230 and 1,100 nM in rat hypothalamic and striatal synaptosomes, respectively). GBR 12783 (10 mg/kg, i.p.) improves learning and memory in the passive avoidance test in rats, an effect that can be blocked by the anticholinergic agent scopolamine.{51541} It increases locomotor activity, reduces pentobarbital-induced sleep duration, and decreases immobility time in the forced swim test, in mice.{51542} GBR 12783 (10 mg/kg) inhibits catalepsy induced by the antipsychotic haloperidol (Item No. 12014) in rats.
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