Formulation: A solution in ethanol
Formal Name: 1,7-bis(4E-hydroxy-3-methoxyphenyl)-4-hepten-3-one
Purity: ≥98%
Formula Markup: C21H24O5
Formula Weight: 356,4
Shelf life (days): 730
CAS Number: 128700-97-0
Notes: Gingerenone A is a diarylheptanoid and polyphenol that has been found in Z. officinale and has diverse biological activities.{62845,62846,62847,62848,62849} It inhibits tyrosinase (IC50 = 9.4 µM for the mushroom enzyme) and scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 12.6 µM).{62845,62846} Gingerenone A (5 and 10 µM) also inhibits JAK2 and p70 ribosomal S6 kinase 1 (p70S6K1).{62847} It selectively decreases the viability of ionizing radiation-induced senescent WI38 fibroblasts over proliferating fibroblasts when used at a concentration of 20 µM.{62848} Gingerenone A (50 mg/kg) prevents increases in body weight but does not affect caloric intake in a mouse model of high-fat diet-induced obesity.{62849} It decreases tumor weight in an HCT116 colon cancer mouse xenograft model when administered at doses of 5 and 20 mg/kg.{62847}
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