GNF-362, CAS 1003019-41-7

Formulation: A solid

Formal Name: 4-[4-[[(3R)-3-methyl-4-[5-(trifluoromethyl)-2-pyridinyl]-1-piperazinyl]methyl]-1H-pyrazol-3-yl]-benzonitrile

Purity: ≥98%

Formula Markup: C22H21F3N6

CAS Number: 1003019-41-7

Notes: GNF-362 is an inositol triphosphate 3 kinase (ITPK) inhibitor (IC50s = 20, 9, and 19 nM for ITPKA, ITPKB, and ITPKC, respectively).{67649} It induces calcium influx in isolated mouse splenocytes (EC50 = 12 nM). In vivo, GNF-362 (10 and 25 mg/kg) reduces the number of thymic CD4+ T cells in mice. It also reduces inflammatory cell infiltration, joint erosion, and proteoglycan loss, in a rat model of antigen-induced arthritis when administered at a dose of 20 mg/kg.

• SKU: CAY35866-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35866-10
• Package Unit: 10 mg
• Quantity Unit: STK