GPX4 Inhibitor 26a, CAS 2761004-85-5

Formulation: A crystalline solid

Formal Name: α-[(2-chloroacetyl)[4-(5-oxazolyl)phenyl]amino]-N-(2-phenylethyl)-benzo[b]thiophene-3-acetamide

Purity: ≥98%

Formula Markup: C29H24ClN3O3S

Formula Weight: 530

Shelf life (days): 1460

CAS Number: 2761004-85-5

Notes: GPX4 inhibitor 26a is an inhibitor of glutathione peroxidase 4 (GPX4).{72057} It inhibits GPX4 activity by 71.7% at 1 µM. GPX4 inhibitor 26a is cytotoxic to 4T1 and MCF-7 breast cancer cells and HT-1080 fibrosarcoma cells (IC50s = 0.78, 6.9, and 0.15 µM, respectively). It decreases intracellular glutathione (GSH) levels and induces lipid peroxidation and ferroptosis in 4T1 cells when used at a concentration of 5 µM. GPX4 inhibitor 26a (15 and 30 mg/kg) reduces tumor growth in a 4T1 mouse xenograft model.

• SKU: CAY35408-1
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35408-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe