GSK843, CAS 1601496-05-2

Formulation: A solid

Formal Name: 3-(5-benzothiazolyl)-7-(1,3-dimethyl-thieno[3,2-c]pyridin-4-amine

Purity: ≥98%

Formula Markup: C19H15N5S2

Formula Weight: 377,5

Shelf life (days): 1460

CAS Number: 1601496-05-2

Notes: GSK843 is an inhibitor of receptor-interacting serine/threonine kinase 3 (RIPK3; IC50 = 6.5 nM).{69547} It is selective for RIPK3 over a panel of 300 additional kinases at 1 µM. GSK843 (10 µM) induces apoptosis in L-929 fibroblasts. It inhibits TNF-α-induced necroptosis in primary human neutrophils in a concentration-dependent manner. GSK843 (3 µM) also inhibits necrosis induced by the toll-like receptor 3 (TLR3) agonist poly (I:C) in IFN-β-primed 3T3-SA fibroblasts.{37147} Intrathecal administration of GSK843 (5 µl of a 13 mM solution) increases the paw withdrawal threshold and latency in a mouse model of inflammatory pain induced by complete Freund’s adjuvant.{66661}

• SKU: CAY39835-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39835-5
• Package Unit: 5 mg
• Quantity Unit: STK