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Background: GW788388 is a potent inhibitor of the TGF-β receptor type 1 (TβRI) and blocks the activation by TGF-β1 of Smad, having an impact on EMT (epithelial to mesenchymal transition of tissues and cells. The use of this inhibitor has proved relevant in the treatment of Chagas heart disease, by reducing cardiac fibrosis.
CAS Number: 452342-67-5
Description: GW788388 is an inhibitor of TGF-β receptor kinases ALK4 (, ALK5, ALK7, and TGFβRII.
Purity: ≥98% by HPLC
Storage Stability: Upon receipt, store at -20°C. Stable for 2 years from date of receipt, when stored as directed. Solutions are stable for up to 1 month at -20°C.
Supplied As: Solid
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
References: Lho Y., et al., 2021 Int J Mol Sci 22(9):4739.
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