HUP-55

Formulation: A solution in acetonitrile

Formal Name: (S)-1-(4-methyl-2-(3-phenylpropyl)oxazol-5-yl)pyrrolidine-2-carbonitrile

Purity: ≥98%

Formula Markup: C18H21N3O

Formula Weight: 295,4

Shelf life (days): 730

Notes: HUP-55 is an inhibitor of prolyl endopeptidase (IC50 = 5 nM).{72022} It reduces α-synuclein dimerization in Neuro2a cells, induces autophagy in HEK293 cells, and decreases hydrogen peroxide-induced increases in reactive oxygen species (ROS) production in SH-SY5Y cells when used at a concentration of 10 µM. HUP-55 (10 mg/kg) decreases ipsilateral paw use and striatal oligomeric α-synuclein levels in a mouse model of Parkinson’s disease induced by adenoviral delivery of an α-synuclein-encoding vector (AAV-αSyn).

• SKU: CAY39117-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 39117-10
• Green Labware: No
• Package Unit: 10 mg
• Quantity Unit: STK