I-BET-762, CAS 1260907-17-2

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Background: Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.

CAS Number: 1260907-17-2

Description: I-BET-762 is a small molecule inhibitor of the BET family of bromodomaincontainingproteins. It has been shown to bind to the acetylated lysine recognition motifs on thebromodomain of BET proteins. This binding prevents the interaction of between BET proteinsand acetylated histone peptides.

Solubility: Soluble in Water

Storage Stability: Powder is stable at -20°C for up to 3 years. Re-suspended powder is stableat -80°C for up to 6 months.

Target: BET

Biosafety Level: Not applicable (BSL-1)

References: Nicodeme E, et al. Nature. 2010 Dec 23;468 (7327):1119-23.

• SKU: BPS27630-1
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27630-1
• Green Labware: No
• Package Unit: 5 mg
• Quantity Unit: STK