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Background: Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
CAS Number: 1260907-17-2
Description: I-BET-762 is a small molecule inhibitor of the BET family of bromodomaincontainingproteins. It has been shown to bind to the acetylated lysine recognition motifs on thebromodomain of BET proteins. This binding prevents the interaction of between BET proteinsand acetylated histone peptides.
Solubility: Soluble in Water
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Target: BET
Biosafety Level: Not applicable (BSL-1)
References: Nicodeme E, et al. Nature. 2010 Dec 23;468 (7327):1119-23.
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