Formulation: A solution in ethanol
Formal Name: 1-[7-(3,4-dimethoxyphenyl)-2,3-dihydro-9-[[(3S)-1-methyl-3-piperidinyl] methoxy]-1,4-benzoxazepin-4(5H)-yl]-1-propanone
Purity: ≥98%
Formula Markup: C27H36N2O5
Formula Weight: 468,6
Shelf life (days): 730
CAS Number: 1640282-31-0
Notes: I-CBP112 is an inhibitor of p300 and CREB-binding protein (CBP) histone acetyltransferases.{67112} It binds to the p300 and CBP bromodomains (Kds = 167 and 151 nM, respectively) and is selective for p300 and CBP over BRD4, as well as a panel of 104 nuclear receptors and ion channels and a panel of 32 enzymes at 10 µM. I-CBP112 displaces acetylated histones from CBP in a cell-free assay (IC50 = 170 nM). It reduces colony formation and increases differentiation of primary murine leukemic blasts and delays disease initiation following leukemic blast transplantation into sub-lethally irradiated mice when used at concentrations of 5 and 10 µM.
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