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Biological Activity: IBMX inhibits PDEs as listed below.
PDE IC50:
PDE1 19 µM
PDE2 50 µM
PDE3 18 µM
PDE4 13 µM
PDE5 32 µM
PDE7 7 µM
PDE11 50 µM
CAS Number: 28822-58-4
Description: IBMX, also known as 1-Methyl-3-Isobutylxanthine and Isobutylmethylxanthine, is a widely-used inhibitor of cAMP and cGMP PDEs. It has been shown that the increase in cellular cAMP and cGMP levels, resulting from the inhibition of PDEs by IBMX, activates cyclicnucleotide-regulated protein kinases. IBMX does not inhibit PDE8A, PDE8B, or PDE9.
Format: A crystalline solid
Purity: ≥98% by HPLC
Solubility: Solubility in ethanol is ~5 mg/ml and DMSO is ~10 mg/ml. For biologicalexperiments, dilute the organic solvent into aqueous buffers or isotonic saline.
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Fawcett, L., et al., Proc. Natl. Acad. Sci. USA 2000; 97(7): 3702-3707.
2. Snyder, S.H., et al., Proc. Natl. Acad. Sci. USA 1981; 78(5): 3260-3264.
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