Formulation: A solid
Formal Name: (±)-α-methyl-4-(2-methylpropyl)-benzeneacetic acid-d3, monosodium salt
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C13H14D3O2 • Na
Formula Weight: 231,3
Shelf life (days): 1460
CAS Number: 1219805-09-0
Notes: (±)-Ibuprofen-d3 is intended for use as an internal standard for the quantification of (±)-ibuprofen (Item No. 70280) by GC- or LC-MS. (±)-Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) and non-selective COX inhibitor (IC50s = 2.6 and 1.3 µM for human recombinant COX-1 and COX-2, respectively).{1364} In vivo, (±)-ibuprofen inhibits late-phase formalin-induced paw licking in mice (ED50 = 6.1 mg/kg).{57951} It also inhibits acetic acid-induced writhing in mice (ED50 = 0.47 mg/kg). Formulations containing (±)-ibuprofen have been used in the treatment of fever and mild to severe pain.
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