Formulation: A solid
Formal Name: N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4′-(trifluoromethyl)[1,1′-biphenyl]-4-yl]-1H-pyrazole-3-propanamide
Purity: ≥98%
Formula Markup: C30H30F3N5O
Formula Weight: 533,6
Shelf life (days): 1460
CAS Number: 1333146-24-9
Notes: ILK-IN-2 is an inhibitor of integrin-linked kinase (ILK; IC50 = 0.6 µM).{67063} It inhibits the phosphorylation of Akt, glycogen synthase kinase 3β (GSK3β), and myosin light-chain (MLC) in PC3 prostate and MDA-MB-231 breast cancer cells when used at concentrations ranging from 1 to 4 µM. ILK-IN-2 inhibits the proliferation of LNCaP, PC3, MDA-MB-231, MDA-MB-468, SK-BR-3, and MCF-7 cancer cells (IC50s = 1.6, 2, 1, 1.5, 1.8, and 2.5 µM, respectively), as well as induces autophagy and apoptosis in PC3 cells when used at a concentration of 2 µM. It also reduces protein levels of Y-box binding protein (YB-1), HER2, and EGFR in PC3 cells. ILK-IN-2 (25 and 50 mg/kg) reduces tumor growth in a PC3 mouse xenograft model.
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