Imidaprilat, CAS 89371-44-8

Formulation: A solid

Formal Name: 3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]-1-oxopropyl]-1-methyl-2-oxo-4S-imidazolidinecarboxylic acid

Purity: ≥95%

Formula Markup: C18H23N3O6

CAS Number: 89371-44-8

Notes: Imidaprilat is an inhibitor of angiotensin-converting enzyme (ACE; IC50 = 2.6 nM) and an active metabolite of the prodrug imidapril (Item No. 18854).{30612} It inhibits bradykinin-induced contractions in isolated guinea pig ileum (IC50 = 1.7 nM). Imidaprilat (50 nM) reduces adhesion induced by chemokine (C-C-) motif ligand 2 (CCL2) of THP-1 monocytes to TNF-α-activated human umbilical vein endothelial cells (HUVECs).{65971} In vivo, imidaprilat (1 mg/kg) inhibits the angiotensin I-induced pressor response in unanesthetized normotensive rats.{30612}

• SKU: CAY38046-500
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38046-500
• Package Unit: 500 µg
• Quantity Unit: STK