Imirestat, CAS 89391-50-4

Formulation: A solid

Formal Name: 2,7-difluoro-spiro[9H-fluorene-9,4′-imidazolidine]-2′,5′-dione

Purity: ≥98%

Formula Markup: C15H8F2N2O2

Formula Weight: 286,2

Shelf life (days): 1460

CAS Number: 89391-50-4

Notes: Imirestat is an inhibitor of aldose reductase (IC50s = 24 and 18 nM for the rat and human enzymes, respectively).{66922} It reduces periodontal bone loss in a rat model of P. gingivalis LPS-induced periodontal inflammation and bone reabsorption when administered in the diet at 0.0125% (w/w).{66923} Dietary administration of imirestat (0.0125% w/w) decreases the incidence and severity of cataracts in a rat model of streptozotocin-induced diabetes.{66924}

• SKU: CAY41829-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 41829-10
• Package Unit: 10 mg
• Quantity Unit: STK