Inflammasome Inhibitor 4b, CAS 2768759-64-2

Formulation: A crystalline solid

Formal Name: N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide, monosodium salt

Purity: ≥98%

Formula Markup: C16H19N2O5S • Na

Formula Weight: 374,4

Shelf life (days): 730

CAS Number: 2768759-64-2

Notes: Inflammasome inhibitor 4b is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation.{62829} It inhibits ATP-induced IL-1β release by 98.3% in LPS-primed mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Inflammasome inhibitor 4b (3 and 10 mg/kg) decreases paw swelling and mechanical hyperalgesia in a mouse model of gout induced by monosodium urate crystals.

• SKU: CAY37030
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37030-1
• Green Labware: No
• Package Unit: 1 mg
• Quantity Unit: STK
• Application: Reinstoffe