IPN60090, CAS 1853164-83-6

Formulation: A solid

Formal Name: 4-[(3,3-difluorocyclobutyl)oxy]-N-[6-[(3R)-3-fluoro-4-[4-[(methylamino)carbonyl]-1H-1,2,3-triazol-1-yl]butyl]-3-pyridazinyl]-6-methyl-2-pyridineacetamide

Purity: ≥98%

Formula Markup: C24H27F3N8O3

CAS Number: 1853164-83-6

Notes: IPN60090 is an inhibitor of glutaminase 1 (GLS1; IC50 = 0.031 µM for the glutaminase C isoform).{68697} It is selective for GLS1 over GLS2 (IC50 = >50 µM), as well as panels of 80 ion channels and receptors and 97 kinases at 10 µM. IPN60090 also binds to zinc finger SWIM domain-containing protein 4 (ZSWIM4; Kd = 2.98 µM).{68698} It decreases the viability of A549 non-small cell lung cancer (NSCLC) cells (IC50 = 26 nM) and decreases glycine levels in OVCAR-8 and SKOV3 ovarian cancer cells.{68697,68698} IPN60090 (30 mg/kg, p.o.), in combination with the DNA-crosslinking agent carboplatin (Item No. 13112), decreases tumor weight and volume in a SKOV3 mouse xenograft model.{68698}

• SKU: CAY35855-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35855-5
• Package Unit: 5 mg
• Quantity Unit: STK