IRAK4 Inhibitor 28, CAS 2196204-23-4

Formulation: A solid

Formal Name: N-[trans-4-(4-morpholinyl)cyclohexyl]-5-(tetrahydro-2H-pyran-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

Purity: ≥95%

Formula Markup: C21H31N5O2

Formula Weight: 385,5

Shelf life (days): 1460

CAS Number: 2196204-23-4

Notes: IRAK4 inhibitor 28 is an inhibitor of IL-1 receptor-associated kinase 4 (IRAK4; IC50 = 0.005 µM).{67645} It is selective for IRAK4 over IRAK1, CDC-like kinase 1 (Clk1), and Clk3 (IC50s = 0.023, 0.05, and >1 µM, respectively) but does inhibit Clk2, Clk4, and haspin (IC50s = 0.005, 0.008, and 0.004 µM, respectively). IRAK4 inhibitor 28 (0.12-3.3 µM) inhibits IκBα phosphorylation in OCI-LY10 diffuse large B cell lymphoma (DLBCL) cells. In vivo, IRAK4 inhibitor 28 (12.5 mg/kg) reduces tumor volume in an OCI-LY10 mouse xenograft model.

• SKU: CAY40167-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 40167-5
• Package Unit: 5 mg
• Quantity Unit: STK