Irsogladine , CAS 57381-26-7

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Background: Irsogladine is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. It is a potent inhibitor of angiogenesis in wild-type and plasminogen activator-deficient mice. Inhibition of PDE4 prevents the hydrolysis of cAMP, an important secondary messenger molecule that is heavily involved in signal transduction.

CAS Number: 57381-26-7

Description: Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Format: White crystalline powder

Solubility: Soluble in DMSO

Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

Target: PDE4

Biosafety Level: Not applicable (BSL-1)

• SKU: BPS27754
• Manufacturer: BPS Bioscience
• Manufacturer SKU: 27754
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK