Product Description: IWP-2 (GMP) is IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation[1].
Applications: Cancer-programmed cell death
Formula: C22H18N4O2S3
Citations: Nat Protoc. 2024 Mar 28./ACS Comb Sci. 2019 Dec 9;21(12):805-816./Adv Mater. 2021 Oct 10;e2104829./Autoimmunity. 2023 Dec;56(1):2182741./Biochem Pharmacol. 2019 Nov;169:113608./Bioengineering (Basel). 2023 Jun 9, 10(6), 702./bioRxiv. 2024 Mar 13./Cell Rep Methods. 2024 May 8:100777./Clin Sci. 2023 Jan 13;137(1):109-127./Dev Cell. 2020 Dec 21;55(6):679-694.e11./Exp Cell Res. 2022 Nov 11;422(1):113416./Exp Ther Med. 2020 Mar;19(3):1701-1710./J Cell Physiol. 2020 Jul;235(7-8):5811-5822./Patent. US20180263995A1./PLoS One. 2024 Jan 5;19(1):e0287206./SSRN. 2024 Mar 26./Stem Cells Transl Med. 2021 May;10(5):743-755.
References: [1]Guan J et al. Chemical reprogramming of human somatic cells to pluripotent stem cells. Nature. 2022;605(7909):325-331. /[2]Hamad S, et al. Generation of human induced pluripotent stem cell-derived cardiomyocytes in 2D monolayer and scalable 3D suspension bioreactor cultures with reduced batch-to-batch variations. Theranostics. 2019 Sep 25;9(24):7222-7238. /[3]Le MNT, et al. Auto/paracrine factors and early Wnt inhibition promote cardiomyocyte differentiation from human induced pluripotent stem cells at initial low cell density. Sci Rep. 2021 Nov 2;11(1):21426. /[4]Taniguchi J, et al. A synthetic DNA-binding inhibitor of SOX2 guides human induced pluripotent stem cells to differentiate into mesoderm. Nucleic Acids Res. 2017 Sep 19;45(16):9219-9228. /[5]Lian X, Zhang J, et al. Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. Nat Protoc. 2013 Jan;8(1):162-75.
CAS Number: 686770-61-6
Molecular Weight: 466.60
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: Wnt
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