JAK3-IN-2, CAS 1443235-95-7

Formulation: A solid

Formal Name: 4-[3-[(2-methyl-1-oxo-2-propen-1-yl)amino]phenyl]-7H-pyrrolo[2,3-d]pyrimidine-5-carboxylic acid, ethyl ester

Purity: ≥95%

Formula Markup: C19H18N4O3

Formula Weight: 350,4

Shelf life (days): 1460

CAS Number: 1443235-95-7

Notes: JAK3-IN-2 is an inhibitor of JAK3 (Ki = 0.07 nM).{68512} It is selective for JAK3 over JAK1 and JAK2 (Kis = 320 and 740 nM, respectively). JAK3-IN-2 inhibits IL-2-induced STAT5 gene expression in a reporter assay (IC50 = 70 nM). In vivo, JAK3-IN-2 (100, 300, and 600 mg/kg) reduces paw swelling and ankle bone loss in a rat model of collagen-induced arthritis.

• SKU: CAY37344-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 37344-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK