Formulation: A solid
Formal Name: 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-2-propen-1-one
Purity: ≥95%
Formula Markup: C17H15FO4
Formula Weight: 302,3
Shelf life (days): 1460
CAS Number: 937820-89-8
Notes: JC2-11 is an inflammasome inhibitor.{66930} It inhibits increases in IL-1β production induced by the NOD-like receptor protein 3 (NLRP3) activators ATP (Item Nos. 14498 / 40182), nigericin (Item No. 11437), or monosodium urate crystals in LPS-primed primary mouse bone marrow-derived macrophages (BMDMs) when used at concentrations of 50 or 100 µM. JC2-11 (100 µM) inhibits increases in IL-1β production induced by flagellin or dsDNA, which are activators of NLR family CARD domain-containing protein 4 (NLRC4) and absent in melanoma 2 (AIM2), respectively, in LPS-primed primary mouse BMDMs. It also scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 52.5 µM) and inhibits LPS-induced nitric oxide (NO) production in primary rat microglial cells.{66931} JC2-11 (10 mg/kg) inhibits LPS-induced increases in IL-1β production in peritoneal lavage fluid in mice.{66930}
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