JNK Inhibitor VIII, CAS 894804-07-0

Formulation: A crystalline solid

Formal Name: N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-benzeneacetamide

Purity: ≥98%

Formula Markup: C18H20N4O4

Formula Weight: 356,4

Shelf life (days): 730

CAS Number: 894804-07-0

Notes: JNK inhibitor VIII is an inhibitor of JNK1, JNK2, and JNK3 (Kis= 2, 4, and 52 nM, respectively).{26046} It is selective for JNK1, JNK2, and JNK3 over a panel of 74 kinases (Kis = >720 nM for all). It inhibits the phosphorylation of c-Jun in HepG2 cells (EC50 = 920 nM). JNK inhibitor VIII (10 µM) inhibits NGF-induced neuronal growth and proNGF-induced neurotoxicity of primary mouse superior cervical ganglion neurons.{62805} It reduces apoptosis induced by glutathione peroxidase 1 (GPX1) siRNA knockdown in HeLa cells when used at a concentration of 10 µM.{62806}

• SKU: CAY15946-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 15946-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK