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Biological Activity: Kaempferol inhibits proliferation of ovarian cancer cells at 40 µM or higher concentrations
CAS Number: 520-18-3
Description: Naturally occurring flavonoid found in Gingko biloba and red wines that activates the mitochondrial Ca2+ uniporter (EC50 = 7 µM). Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Pan-HDAC inhibitor; in vitro profiling of all conserved human HDACs of class I, II and IV showed that kaempferol inhibited all tested HDACs.
Format: yellow coloured powder
Solubility: Soluble in DMSO (100 mM) and ethanol (100 mM)
Storage Stability: Store at or below +4°C. Solid form is stable at least 12 months from date of receipt, when stored as directed.
Target: HDAC
Biosafety Level: Not applicable (BSL-1)
References: 1. Kim SH, Choi KC. Toxicol Res. 2013 Dec 31;29(4):229-34.
2. Chen AY, Chen YC. Food Chem. 2013 Jun 15;138(4):2099-107.
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