KAT8 Inhibitor 19, CAS 28532-21-0

Formulation: A solid

Formal Name: 4-[4,5-dihydro-3-methyl-5-oxo-4-(1H-pyrrol-2-ylmethylene)-1H-pyrazol-1-yl]-benzoic acid

Purity: ≥98%

Formula Markup: C16H13N3O3

Formula Weight: 295,3

Shelf life (days): 1460

CAS Number: 28532-21-0

Notes: KAT8 inhibitor 19 is an inhibitor of lysine acetyltransferase 8 (KAT8; IC50 = 12.1 µM).{72287} It is selective for KAT8 over KAT2A, KAT2B, KAT3B, KAT6A, and KAT7 at 200 µM. KAT8 (50 µM) reduces histone 4 lysine 16 acetylation (H4K16Ac) in HT-29 colorectal carcinoma cells. It reduces the viability of HCT116, H1299, A549, and U937 cancer cells (IC50s = 39.4, 52.1, 41, and 30.1 µM, respectively).

• SKU: CAY38977-10
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 38977-10
• Package Unit: 10 mg
• Quantity Unit: STK