Formulation: A solution in ethanol
Formal Name: (2S)-1-[[(2S)-1-(1-oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Purity: ≥98%
Formula Markup: C20H25N3O2
Formula Weight: 339,4
Shelf life (days): 730
CAS Number: 796874-99-2
Notes: KYP-2047 is an inhibitor of prolyl endopeptidase (Ki = 0.02 nM for the porcine enzyme).{51727} It inhibits hydrogen peroxide-induced aggregation of α-synuclein in SH-SY5Y cells expressing wild-type, α-synucleinA30P, or α-synucleinA53T in in vitro models of Parkinson’s disease when used at a concentration of 1 µM.{51728} KYP-2047 (10 µM) decreases lipid peroxidation and the production of reactive oxygen species (ROS) induced by palmitic acid (Item No. 10006627) in HepG2 cells.{51729} It decreases ileal and pulmonary edema and pulmonary fibrosis in a mouse model of acute lung injury induced by intestinal ischemia-reperfusion when administered at a dose of 2.5 mg/kg.{51730} KYP-2047 (2.5 mg/kg) reduces tumor volume and intratumoral levels of Vegf and Cd34, markers of angiogenesis, in a U87 glioblastoma mouse xenograft model.{51726}
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