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Applications: Useful for inhibition of the 20S proteasome.
CAS Number: 133343-34-7
Description: Lactacystin is a cell-permeable, potent and selective proteasome inhibitor that binds irreversibly to the catalytic beta-subunit of the 20S proteasome inhibiting its chymotrypsin-like and trypsin-like activities. Also known to inhibit NF-κappaB activation (IC50 = 10 µM).
Format: White powder
Purity: >99% by TLC.
Solubility: Soluble in Water (10 mg/ml) or DMSO (20 mg/ml)
Warnings: Protect from light. Protect from moisture. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Fenteany, et al. Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 1995, 268:726.
2. Kozlowski, L. et al. Lactacystin inhibits cathepsin A activity in melanoma cell lines. Tumour Biol. 2001, 22:211.
3. Pasquini, L.A. et al. Lactacystin, a specific inhibitor of the proteasome, induces apoptosis and activates caspase-3 in cultured cerebellar granule cells. J. Neurosci Res. 2000, 59:601.
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