Formulation: A crystalline solid
Formal Name: 4-amino-1-[(2R,5S)-2-(hydroxymethyl)1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone
Purity: ≥98%
Formula Markup: C8H11N3O3S
Formula Weight: 229,3
Shelf life (days): 1460
CAS Number: 134678-17-4
Notes: Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI).{7205} It is phosphorylated intracellularly to its active form lamivudine-5'-triphosphate by the successive actions of deoxycytidine kinase, cytidine monophosphate kinase, and deoxycytidine monophosphate kinase. It reduces HIV-1 p24 antigen levels in the culture supernatant of human peripheral blood lymphocytes infected with laboratory-adapted HIV-1 strains, indicating inhibition of HIV replication, with IC50 values ranging from 0.0025 to 0.09 µM.{65116} Lamivudine inhibits syncytium formation between various CD4+ cell lines and several strains of HIV-1 or HIV-2 (IC50s = 0.014-0.61 µM). It reduces serum viral titers in a woodchuck model of chronic hepatitis B virus (HBV) infection when administered at doses of 40 or 200 mg/kg.{65117} Formulations containing lamivudine have been used in the treatment of HIV and HBV infections.
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