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Applications: Useful for the inhibition of Ubiquitin C-terminal Hydrolase (UCH-L1) in drug discovery studies.
CAS Number: 668467-91-2
Description: LDN-57444 is a cell permeable ubiquitin C-terminal hydrolase (UCH-L1) inhibitor (Ki=0.4 µM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis and causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. LDN-57444 is a useful tool to study UCH-L1 in different pathological conditions such as cancer and neurodegeneration.
Format: Yellow powder
Purity: ≥98% by TLC.
Solubility: Soluble in DMSO (20 mg/ml)
Storage Stability: Store at +4°C. Stable as supplied for up to 2 years when stored dessicated at +4°C. Store solutions at -20°C for up to 1 week.
Warnings: Protect from moisture. Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
References: 1. Tan, et al Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol.Cell.Biochem. 318:109 (2008).
2. Susor, A., et al., Proteomic analysis of porcine oocytes during in vitro maturation reveals essential role for the ubiquitin C-terminal hydrolase-L1. Reprod. 134:559 - 568, (2007) .
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