Linderalactone, CAS 728-61-0

Formulation: A solid

Formal Name: (4R,10E)-4,8,9,12-tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one

Purity: ≥98%

Formula Markup: C15H16O3

CAS Number: 728-61-0

Notes: Linderalactone is a sesquiterpene lactone that has been found in L. aggregate and has anticancer and antioxidant activities.{67801,67802,67803} It is an inhibitor of α-glucosidase (IC50 = 12.72 µM).{67801} Linderalactone inhibits the proliferation of A549 lung cancer cells (IC50 = 15 µM).{67802} It also induces apoptosis and cell cycle arrest at the G2/M phase and reduces the levels of unphosphorylated and phosphorylated JAK1, JAK2, STAT1, and STAT2 in A549 cells in a concentration-dependent manner. Linderalactone reduces hydrogen peroxide-induced increases in cell death in HepG2 cells (EC50 = 98 µM).{67803}

• SKU: CAY35641-5
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 35641-5
• Package Unit: 5 mg
• Quantity Unit: STK