Formulation: A solid
Formal Name: (S)-2-amino-N,3-dihydroxy-N-(14-methyl-3,10-dioxopentadecyl)propanamide, hemisulfate
Purity: ≥98%
Formula Markup: C19H36N2O5 • 1/2H2SO4
CAS Number: 11075-87-9
Notes: Lipoxamycin is an inhibitor of serine palmitoyltransferase (SPT; IC50 = 21 nM for the S. cerevisiae enzyme) and an antifungal agent.{72307} It also inhibits human SPT with an IC50 value approximately 10-fold lower than the S. cerevisiae enzyme. Lipoxamycin is active against several species of Candida and Cryptococcus, as well as S. cerevisiae (MICs = 0.5-16, 0.25-0.5, and 16 µg/ml, respectively).