Formulation: A solid
Formal Name: lup-20(29)-en-3-one
Purity: ≥98%
Formula Markup: C30H48O
Formula Weight: 424,7
Shelf life (days): 1460
CAS Number: 1617-70-5
Notes: Lupenone is a triterpenoid that has been found in L. eriocalyx and has diverse biological activities.{52302,61999,52304,61250} It inhibits HIV-1 reverse transcriptase (IC50 = 2.1 μM).{52302} Lupenone is active against the W2 and D6 strains of P. falciparum (IC50s = 208.1 and 394.7 ng/ml, respectively).{61999} It induces melanogenesis in (EC50 = 0.35 µM), and inhibits the growth of, B16 2F2 melanoma cells in vitro (IC50 = 25.4 µM).{52304} Topical application of lupenone (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{61250} It also inhibits acetic acid-induced writhing in mice when administered at a dose of 100 mg/kg.{61999}
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