LY2603618, CAS 911222-45-2

Formulation: A crystalline solid

Formal Name: N-[5-bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy]phenyl]-N'-(5-methyl-2-pyrazinyl)-urea

Purity: ≥95%

Formula Markup: C18H22BrN5O3

Formula Weight: 436,3

Shelf life (days): 1460

CAS Number: 911222-45-2

Notes: LY2603618 is a checkpoint kinase 1 (Chk1) inhibitor (IC50 = 7 nM) that prevents the repair of DNA caused by DNA-damaging agents.{32250} It can inhibit Chk1 autophosphorylation and increase DNA damage-mediated Chk1 phosphorylation.{32251} LY2603618 has been used in xenograft tumor models to potentiate the antitumor efficacy of chemotherapeutic agents such as gemcitabine (Item No. 11690).{32249}

• SKU: CAY20351-50
• Manufacturer: Cayman Chemical
• Manufacturer SKU: 20351-50
• Green Labware: No
• Package Unit: 50 mg
• Quantity Unit: STK
• Application: Reinstoffe