Formulation: A solid
Formal Name: 9-fluoro-2,3-dihydro-3-methyl-10-(4-methyl-1-piperazinyl-d8)-7-oxo-7H-pyrido[3,2,1-ij][4,1,2]benzoxadiazine-6-carboxylic acid, monohydrochloride
Purity: ≥99% deuterated forms (d1-d8)
Formula Markup: C17H11D8FN4O4 • HCl
Formula Weight: 406,9
Shelf life (days): 1460
Notes: Marbofloxacin-d8 is intended for use as an internal standard for the quantification of marbofloxacin (Item No. 24174) by GC- or LC-MS. Marbofloxacin is a fluoroquinolone antibiotic that is active against P. multocida in vitro (MIC = 0.016 μg/ml).{39533} It exhibits broad-spectrum antibacterial activity mediated by the inhibition of DNA gyrase, with MIC values ranging from 0.016 to 0.4 and 0.19 to 1.7 µg/ml against various Gram-negative and Gram-positive bacterial isolates, respectively.{39536} Intramuscular administration of marbofloxacin (2 mg/kg) after infection prevents the formation of pulmonary lesions in a bovine calf model of M. haemolytica A1 pneumonia.{39534} Oral administration of marbofloxacin (2 mg/kg per day) also exhibits antileishmanial activity in a canine model of leishmaniasis, decreasing parasitic load by 72%.{39535} Formulations containing marbofloxacin have been used in the veterinary treatment of bacterial infections.
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