Notes: Mastoparan 7 is a G protein activator and derivative of the mast cell degranulating peptide mastoparan (Item No. 20240).{33682} It decreases the affinity of acetylcholine (ACh) to porcine brain muscarinic ACh receptors (mAChRs) when used at a concentration of 30 µM and induces GDP/GTP exchange by Gi in a concentration-dependent manner. Mastoparan 7 (1 µM) also induces activation of Gαo in, and increases dendritic spine density of, primary rat hippocampal neurons.{68620} It induces contractions in isolated perfused rat tail arteries (EC50 = 44.1 nM).{68621} Immunization with a vaccine against cocaine in combination with mastoparan 7 as an adjuvant increases hapten-specific serum IgG levels and decreases cocaine-induced locomotion in mice.{68622}